The Term Large Volume Parenteral (LVP) Refers To Sterile Preparations Of 250 ML Or More Administered Parenterally

 

Large Volume Parenteral (LVP) 

Parenteral Medications are sterile dose forms that are supplied by a different method than the oral route. The active substance is immediately in contact with tissue or a blood vessel after being injected into one or more layers of skin. Small volume parenterals are single or multiple dosage preparations having a volume of 100 ml or less, whereas Large Volume Parenteral have a volume greater than 100 ml. Large volume parenteral is administered intravenously and comes in a bag or bottle. It is used to correct the fluid/electrolyte balance and supply nourishment, such as dextrose.

Injectable aqueous Medication products that have been terminally sterilised (by autoclave) and packaged in single dose containers typically have a capacity of 100 ml or more are known as Large Volume Parenteral (LVPs) (usually up to 1 liter). While the active medicinal ingredients in large volume parenterals can vary, water is almost usually the main component. Salts, albumin, dextran, salts ranging from 5% to 50%, and amino acids changing in percentage are typical examples. Thousands of litres or more are typically the size of production batch sizes.

Applications of Large Volume Parenteral-

·        Fluid Balance Therapy

·        Therapeutic Injection

·        Nutritional Therapy

USP Water for Injection, or pyrogen-free water that complies with the requirements of the monograph in the most recent edition of the United States Pharmacopoeia, must be used for product makeup and the final rinse of containers and equipment. There are many instances in which suitable liquid filters are used in the production of LVPs. They help prepare pharmaceutical-grade fluids for cleaning and product makeup, as well as for last filtration to reduce particle and bioburden just before filling and terminal sterilising. The flow diagram that is attached shows a typical pharmaceutical water system. Early in the process, effective pharmaceutical grade depth filters can stop the fouling of downstream components.

 

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