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Swine respiratory disease affects the respiratory tract of swine. It is one of the prevalent cause of death in nursery pigs and grower/finisher pigs. There are multiple pathogens, viruses, and other secondary causative agents that causes respiratory disease in swine. Primary pathogens that causes swine respiratory disease are Actinobacillus pleuropneumoniae (APP), Mycoplasma hyopneumoniae, Bordetella bronchiseptica, and Pasteurella multocida. Viral agents involved are porcine reproductive and respiratory syndrome (PRRS) virus and swine influenza virus (SIV). Various diseases that come under ambit of swine respiratory disease are mycoplasma pneumonia, swine influenza, classical swine fever atrophic rhinitis, pleuropneumonia, porcine reproductive and respiratory syndrome, and porcine circovirus type 2. These infectious agents together increase the severity of the disease. Growing awareness about the health of swine among pork consumers has spurred research on pig's p...