Primary sclerosing cholangitis (PSC) is a condition causing long-term inflammation and scarring (fibrosis) of bile ducts in the liver

 

Primary sclerosing cholangitis (PSC) is a condition causing long-term inflammation and scarring (fibrosis) of bile ducts in the liver. These ducts are tubes that allow the liquid (bile) produced by the liver to pass through the intestine allowing fat digestion. This disease predominantly affects men between the age of 25 and 40 years. The damage to the ducts causes accumulation of bile acids, essential components of bile to build up in the liver leading to liver tissue damage, portal hypertension (high blood pressure in the vessels connecting the liver and the gut), and liver failure, and may increase the risk of liver cancer.

Primary sclerosing cholangitis is a rare disease that has an impact on bile duct. The bile duct becomes scarred in primary sclerosing cholangitis. This in turn affects the functioning of liver. In other words, primary sclerosing cholangitis is a chronic disease that affects the liver and the gallbladder. It is mostly observed in men in the age group of 30-50 years. It leads to clogging of bile ducts leading to accumulation of bile acids, which in turn damages the liver tissues.

Primary Sclerosing Cholangitis (PSC) is an immune-mediated chronic liver disease characterized by inflammation, fibrosis and destruction of intrahepatic and/or extra-hepatic bile ducts leading to cholestasis, bile duct strictures and hepatic fibrosis, which in turn, may progress to cirrhosis, portal hypertension, and hepatic decompensation.

Liver carries out important functions in the body, such as, production of protein, metabolizing of fat and carbohydrate, detoxification of drugs, alcohol, and environmental toxin. Primary sclerosing cholangitis (PSC) is a chronic disease of the liver and gallbladder, characterized by inflammation and scarring of the bile ducts from inside and outside, which normally allow bile to drain from the gallbladder. The ducts carry bile out of the liver. In primary sclerosing cholangitis, the ducts become blocked, causing bile to build up in the liver, which damages the liver cells.

Primary sclerosing cholangitis (PSC) is a condition that leads to long-term inflammation and scarring (fibrosis) of bile ducts in the liver. These ducts are tubes that allow the liquid (bile) produced by the liver to pass through the intestine allowing fat digestion. This disease predominantly affects men, between the 25 and 40 years of age. The damage to the ducts causes accumulation of bile acids, essential components of bile to build up in the liver leading to liver tissue damage, portal hypertension (high blood pressure in the vessels connecting the liver and the gut), and liver failure, and may increase the risk of liver cancer.

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