Unfractionated Heparin: an emerging drug used to treat venous thromboembolism!

 

Unfractionated Heparin is a naturally occurring glycosaminoglycans. As a medical drug, it's mainly used as an antiplatelet. In the medical world, its most commonly referred to as anti-angina, it acts against the primary cause of painful clots that develop in the veins of the legs. Specifically, it's used in the therapy of unstable angina and heart attacks. It's usually given via injection directly into a major vein or underneath the skin.

It is also known as unitary, heparin, or hpt. It's usually marketed as a white blood cell booster. There are many potential side effects when using Unfractionated Heparin which should be considered when deciding whether or not to prescribe it. The most common one is liver damage due to hydration and electrolyte imbalances caused by its breakdown by the liver. Other possible side effects include allergic reactions, hives, rashes, and more.

On top of liver damage, some patients experience allergic reactions to this drug. One type of allergic reaction is called Erythroderma. This is known to occur in one-quarter of patients who start taking the drug and only in twenty-five percent of those who don't. Another type of allergic reaction is known as alkalemia and this typically occurs in twenty-five percent of patients and is associated with hypoxemia, severe anemia, or prolonged hospitalization. Both of these conditions are potentially life-threatening and should be considered when Unfractionated Heparin is being considered for renal clearance.

Venous thromboembolism occurs when the drug's molecules become dislodge from their binding base in the veins of the legs. This condition is known to produce symptoms similar to those of embolism and shock. Unfractionated Heparin's mechanism of action, in which it increases the permeability of capillaries and thickens the arterioles, has been shown to increase the risk of venous thromboembolism in postmenopausal women.

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